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When used on a regular basis, its efficacy begins to deplete with time, reaching a stage when it has no impact on the user. Such a reduction in the neurophysiologic response caused by the usage of the drug over a long period of time is known as Adderall tolerance. When one’s body adapts to the chemical makeup of Adderall, it becomes increasingly resistant to any kind of effects, which eventually leads to Adderall tolerance.

An individual who develops Adderall tolerance increases the dosage of the drug to get the desired effects. While anyone can develop a tolerance to this drug, a person who abuses it for the euphoric effects tends to develop it quicker than those using it for therapeutic purposes.

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Dosage:An individual’s tolerance to Adderall depends on the dosage of the drug administered to him or her on a regular basis. It is best to take the doses as prescribed by the doctor and get them reviewed at least once a year. Usually, the dosage remains the same after the age of 16 years. The greater the dosage, the quicker a person is likely to develop tolerance based on the amount of norepinephrine and dopamine released in the brain. Once a person has reached the highest dosage level, then even decreasing the amount can have repercussions and the risk of heart abnormalities increases significantly.

Frequency of usage:A person who takes Adderall throughout the day is likely to develop tolerance more quickly than others. Moreover, a person consuming a single dose of Adderall IR (instant release) is likely to have the drug in his or her system for a shorter duration compared to those taking Adderall XR (extended release). While the effects of Adderall XR remain for 12 hours, Adderall IR remains active only for four to six hours. Consequently, the likelihood of developing Adderall tolerance is slower in those consuming Adderall IR, as the body remains drug free for a comparatively longer time.

Time span: The tolerance levels of an individual also depends on the time period he or she has been taking that particular dose of Adderall. The risk of developing tolerance increases with the increase in the time span. Compared to those taking this only when needed, those consuming it regularly are likely to develop tolerance quickly. One should also consider the days when the drug has not been used while calculating the total time span.

Other drugs taken with Adderall: A number of drugs or supplements have the potential to accelerate or prolong tolerance to Adderall in a person. By potentiating the effects of Adderall, such as triggering dopamine release, they increase the risk of developing tolerance.

5. Other factors: Apart from the triggers mentioned above, the risk of developing Adderall tolerance also depends on a number of other factors, such as genetics, diet, stress, sleep, etc. People with poor eating habits, sleep, etc., usually witness a low dopamine level while taking this, which, in turn, leads to the development of quicker tolerance.

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One should be cautious while taking this and consult a doctor if he or she notices the signs of developing Adderall tolerance, such as an inability to focus, experiencing a need to have a higher dose to feel its effects, etc. As Adderall tolerance might even cause physical dependence in certain cases, it is recommended to be used as per the prescription.

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